A modern Giallo horror film, CITY OF LUST tells the story of a lonely young woman who begins an unlikely relationship with dire consequences. Arianna is a young woman who moves to the city to escape a traumatic family life in the suburbs. She works as a cosmetologist and is showing early signs of formaldehyde poisoning. New to the city and lonely, she reaches out to a female sex line operator. They agree to meet and soon begin a volatile relationship. An altercation at work results in Arianna losing her job. Then, people in her life begin to turn up dead. With Arianna's health, career, and new relationship all disintegrating before her eyes, how much longer can she, and those around her, survive?